Inhibition of Cas9 by Anti-CRISPR AcrIIA26
This illustration is intended to accompany, and serve as a cover art submission for, research by the Bailey Laboratory at Johns Hopkins.
CRISPR-Cas9 is the best-known gene editing system today. The Bailey Laboratory recently described a new Anti-CRISPR, a class of protein which may act as an “off switch” for CRISPR systems. This Anti-CRISPR, AcrIIA26, prevents Cas9 from binding to DNA by mimicking the Protospacer Adjacent Motif, the Cas9 binding site. AcrIIA26 prevents Cas9 from binding to DNA, and prevents the conformational changes nessary for DNA unwinding and cleavage.
This piece was created with data from Pymol, imported via ePMV and refined in Cinema 4D. I built the DNA using a base I generated with ePMV.
CRISPR-Cas9 is the best-known gene editing system today. The Bailey Laboratory recently described a new Anti-CRISPR, a class of protein which may act as an “off switch” for CRISPR systems. This Anti-CRISPR, AcrIIA26, prevents Cas9 from binding to DNA by mimicking the Protospacer Adjacent Motif, the Cas9 binding site. AcrIIA26 prevents Cas9 from binding to DNA, and prevents the conformational changes nessary for DNA unwinding and cleavage.
This piece was created with data from Pymol, imported via ePMV and refined in Cinema 4D. I built the DNA using a base I generated with ePMV.